March 5, 2025

For time:

21-15-9

Ring Dips

Ring Rows

Overhead Squats (45/35)

Scale first by reducing the reps. Make the ring dips strict, and use the legs if necessary as a scaling option. Make the ring rows hard. Overhead squats should be broken into 2-3 sets on each round.

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Bacon & Eggs on Guac

Here’s a quick and delicious breakfast recipe for Bacon, Egg, and Avocado Breakfast Bowls. It’s simple, hearty, and takes about 20 minutes to make.

Ingredients (Serves 2):

• 4 large eggs

• 4 strips of bacon

• 1 ripe avocado, halved and pitted

• 1 tbsp olive oil or butter (for cooking eggs)

• Salt, to taste

• Black pepper, to taste

• Optional: pinch of chili flakes or chopped fresh cilantro for flavor

Instructions:

1. Cook the Bacon: Heat a skillet over medium heat. Add the bacon strips and cook until crispy, about 4-6 minutes per side, depending on thickness. Remove to a paper towel-lined plate to drain excess grease. Once cooled slightly, crumble or chop into bite-sized pieces.

2. Prepare the Avocado: Scoop the avocado flesh into a small bowl. Mash it lightly with a fork, leaving some chunks for texture. Season with a pinch of salt and pepper. Set aside.

3. Cook the Eggs: In the same skillet (or a fresh one if you prefer), heat the olive oil or butter over medium heat. Crack the eggs into the pan. For sunny-side-up, cook 2-3 minutes until the whites are set but the yolks are still runny. For over-easy, flip after 2 minutes and cook for 1 more minute. Season with salt and pepper to taste.

4. Assemble the Bowls: Divide the mashed avocado between two bowls, spreading it along the bottom. Top each with two cooked eggs. Sprinkle the crumbled bacon over the eggs.

5. Add Finishing Touches: If you like a bit of heat, sprinkle chili flakes on top. For freshness, add a pinch of chopped cilantro.

6. Serve: Enjoy immediately while the eggs are warm and the bacon is crisp!

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Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma

by Thomas Seyfried

Paper: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03775-4

Abstract:

Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a universally lethal prognosis despite maximal standard therapies. Here, we present a consensus treatment protocol based on the metabolic requirements of GBM cells for the two major fermentable fuels: glucose and glutamine. Glucose is a source of carbon and ATP synthesis for tumor growth through glycolysis, while glutamine provides nitrogen, carbon, and ATP synthesis through glutaminolysis. As no tumor can grow without anabolic substrates or energy, the simultaneous targeting of glycolysis and glutaminolysis is expected to reduce the proliferation of most if not all GBM cells. Ketogenic metabolic therapy (KMT) leverages diet-drug combinations that inhibit glycolysis, glutaminolysis, and growth signaling while shifting energy metabolism to therapeutic ketosis. The glucose-ketone index (GKI) is a standardized biomarker for assessing biological compliance, ideally via real-time monitoring. KMT aims to increase substrate competition and normalize the tumor microenvironment through GKI-adjusted ketogenic diets, calorie restriction, and fasting, while also targeting glycolytic and glutaminolytic flux using specific metabolic inhibitors. Non-fermentable fuels, such as ketone bodies, fatty acids, or lactate, are comparatively less efficient in supporting the long-term bioenergetic and biosynthetic demands of cancer cell proliferation. The proposed strategy may be implemented as a synergistic metabolic priming baseline in GBM as well as other tumors driven by glycolysis and glutaminolysis, regardless of their residual mitochondrial function. Suggested best practices are provided to guide future KMT research in metabolic oncology, offering a shared, evidence-driven framework for observational and interventional studies.